delirium detection with an objective medical device


Investigator initiated studies by Prof. Dr. Arjen Slooter (Neurologist-Intensivist at University Medical Center Utrecht, the Netherlands) form the scientific basis of the innovation. As a trained neurologist active in Intensive Care Medicine, Slooter has a special interest for neuropsychiatric disorders in the ICU, particularly delirium. It's his mission to improve delirium detection, to improve patient outcome. Research shows that recognition of delirium is currently poor, even hospital departments that actively use checklists in everyday clinical settings, still miss about 50% of delirium cases. The frequent type of hypoactive delirium is missed in nearly 70% of the cases. 

Therefor Prof. Dr. Slooter and his brain at risk team focussed research on objective tools to detect delirium. The PhD thesis of Willemijn van der Kooi (June 2014) showed that developing an EEG-based monitor is the most promising strategy from various approaches to detect delirium, based on physiological alterations.
In a clinical study in elderly surgery patients it was shown that a short trace of brain activity (EEG) recording using only 3 electrodes is enough to strongly differentiate between delirious and non-delirious patients. In a multicenter technology validation study it was shown that EEG based delirium detection is sensitive and specific and even has prognostic value (PhD thesis of Tianne Numan, Sept 2017).  

Prolira's innovative DeltaScan is based on measuring brain activity (EEG). Delirium leads to slowing in the EEG spectrum.

DeltaScan is intended and designed for daily screening of all patients who are at risk of delirium.
In most countries guidelines prescribe screening at least every 8 hours (=every shift).
Nurses equipped with the portable DeltaScan Monitor and the disposable DeltaScan electrode Patches, can check in a 3-minute process if a patient has delirium or not.